佩乐能-PEGIFN的分子设计及按体重给药研讨.pptVIP

* 聚乙二醇的主要作用是加大分子量降低肾脏清除率和减少免疫原性，避免蛋白酶及免疫细胞的识别和清除 * 这张幻灯片形象的表示，随着PEG 分子量的增大，PEG IFN的分子量越大（对干扰素与受体结合的干扰越大）。 * 经过大量反复试验，先灵葆雅得出结论：随着PEG 分子量的增加，半衰期越来越长。 This cartoon depicts the effect of increased peg-size on half-life. PEG molecules range in molecular weight from 300 to 4000 Daltons can be arranged in linear or branched chains. The extent to which pegylation modifies the pharmacokinetic and pharmacodynamic profile of a native protein depends on the structure and size of the PEG molecule (x-axis) and the site of attachment of the PEG chain. In general, the larger the PEG chain, the greater t