遗传归纳.docVIP

Patterns of inheritance Index case/proband/propositus/proposita: The family tree begins with the person through whom the family came to the attention of the investigator. Determining the patterns: family analysis, index case, pedigree drawing Autosomal inheritance: A trait or disorder that is determined by a gene on an autosome. Sex-linked inheritance: A trait or disorder determined by a gene on one of the sex chromosomes. Heterozygous state: A person posseses both an abnormal or mutant allele and the normal allele. Pleiotropy: A single gene that may give rise to two or more apparent