Week 7 Monday.pptVIP

Chapter 3. Functional Group Interconversionby Substitution, Including Protection and Deprotection Nov. 10th, 2008 Chapter 4. Electrophilic Additionsto Carbon-Carbon MultipleBonds Nov. 10th, 2008 * Benzyl ethers: Bz, PMB, DMB Cleaved by catalytic hydrogenolysis, or by electron-transfer reduction using Na/NH3 or by Lewis acids such as FeCl3 and SnCl4 or by dichlorodicyanoquinone (DDQ). 3.5.1.3. Silyl Ethers as Protective Groups TMS, TES, TBDMS, TBDPS, TPS, TIPS, TBODPS Introduced by halide or triflate Removed by hydrolytic conditions (acidic), or TBAF, methanolic NH4F, or aqueous HF