ATFalpha.pptVIP

Figure 7: ATF6a protects from ER stress in vivo Conclusion ATF6a can bind to ER stress element and regulates the expression of ER stress responsive genes, and this function is overlapped with other ER stress signal pathways IRE1a and PERK. ATF6a participates in regulation of ERAD pathways and apoptosis pathways especially, during chronic ER stress. ATF6a paricipates in regulation of precondition of ER stress. ATF6a is an essential factor for chronic ER stress by regulation of persistent eIf2a phosphorylation,and upregulation of CHOP and GADD34. Thank You * * * * * * * * Cell Stress Response