疏血通注射液治疗瘀血阻络型胸痹临床疗效观察【参考】.docVIP

疏血通注射液治疗瘀血阻络型胸痹临床疗效观察 邢晓梅1 王明利1 王凤云2 1.北京市门头沟区医院 (北京 102300) 2.中国中医科学院西苑医院 (北京 100091) 【摘要】目的 观察疏血通注射液对不稳定型心绞痛的临床疗效。方法 将64例不稳定性心绞痛患者随机分为两组，对照组33例给予常规西药治疗，治疗组31例在常规西药治疗的基础上加用疏血通注射液，3周为1个疗程，观察1个疗程后两组临床症状及水平的变化情况。结果 治疗组临床总有效率为90.32%,明显高于对照组的72.73%(P＜0.05)；治疗组患者治疗后血液PAG、GMP-140及部分血流变性指标水平与对照组比较差异有显著性(P＜0.05或P＜0.01)。结论 疏血通往射液对冠心病不稳定型心绞痛有良好疗效，可能与其降低黏附分子活性、抑制血小板聚集、降低血黏度的作用有关。 【关键词】不稳定心绞痛；胸痹；瘀血阻络；疏血通注射液；血小板；血液流变学 【中图分类号】R256.22；R541.4 【文献标识码】A 【文章编号】1007-1334(2007)11-0035-03 Clinical Observation of Efficacy Of Shuxuetong injection on Unstable Angina Pectoris 1. Mentougou District Hospital, Peking 2. Xiyuan Hospital, China Academy of Chinese Medical Sciences Abstract: Objective To observe the efficacy of shuxuetong injection on unstable angina pectoris. Methods Sixty-four patients with unstable angina pectoris were randomly divided into two groups, 33 cases were treated with conventional medicine in the control group, 31 cases were treated with Shuxuetong injection plus conventional medicine in the treatment group. Changes of clinical symptoms and the levels of PAG、SICAM-1、GMP-140 were measured after three-weeks treatment Results Total effective rate was 72.73% in control group, lower than 90.32% in treatment group, P＜0.05. There are were significant improvement for Shuxuetong group in the levels of scram PAG、SICAM-1 and GMP-140,hemotrrheology indexes after therapy, P＜0.05-0.01 Compared with the control group, the levels of scram PAG、SICAM-1 and GMP-140,hemotrrheology indexes were significant lower, P＜0.05. Conclusion Shuxuetong injection is effective on unstable angina, which potentially due to down-regulate the activity of adhesion molecule, prevent platelet aggregation, reduce blood viscosity. Key words: Unstable angina pectoris; Shuxuetong injection; platelet; homorheology. 不稳定型心绞痛（UA）是急性冠状动脉综合征较常见的急症之一，动脉粥样硬化斑块破裂、血小板激活并血栓形成造成管腔不完全堵塞是其基本病理基础[1]。近年来研究表明，冠状动脉粥样斑块存在着慢性炎症过程，其形成和活动程度与可溶性细胞间黏附分子(SICAM-1)、C反应蛋白等炎性分子及血小板功能有关，可作为临床判断预后和病变严重程度的指标。我科运用疏血通注射液治疗不稳定型心