系统生物学软件-4.pptVIP

系统生物学软件 王 栋 wangdong@ “assigns a score to each gene on the basis of change in gene expression relative to the standard deviation of repeated measurements.” SAM uses permutations of repeated measurements to estimate the False Discovery Rate Paper available online: /~tibs/SAM/pnassam.pdf Reminder: t-Test t-Test for a single gene: We want to know if the expression level changed from condition A to condition B. Null assumption: no change Sample the expression level of the genes in two conditions, A and B. Calculate H0: The grou