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A Good Practice Guide to the Administrationof Substances and Removal of Blood,Including Routes and Volumes JOURNAL OF APPLIED TOXICOLOGY J. Appl. Toxicol. 21, 15–23 (2001) Key words: blood volumes; blood removal; administration substances; laboratory animals; refinement. objectives This article is the result of an initiative between the European Federation of Pharmaceutical Industries Associations (EFPIA) and the European Centre for the Validation of Alternative Methods (ECVAM). Its objectives are to provide the researcher in the safety evaluation laboratory with an up-to-date, easy to-
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