03第03章1-2节吸收与酵解概要.pptVIP

第三章 糖代谢(p315) 第一节 糖的消化吸收 第二节 糖的中间代谢—无氧酵解(p315) Allosteric Regulation of Phosphofructokinase. A high level of ATP inhibits the enzyme by decreasing its affinity for fructose 6-phosphate. AMP diminishes and citrate enhances the inhibitory effect of ATP. Activation of Phosphofructokinase by Fructose 2,6-Bisphosphate. (A) The sigmoidal dependence of velocity on substrate concentration becomes hyperbolic in the presence of 1 μM fructose 2,6-bisphosphate. (B) ATP, acting as a substrate, initially stimulates the reaction. As the concentration of ATP increases, it acts as an allosteric inhibitor