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Coronary blood flow is driven by the pressure difference between the aorta and the capillary bed and modulated further by various physical and neural factors, which affect the microcirculation. Moreover, the different compartments of the microcirculation are influenced by one main physiological mechanism to control their vascular tone with cardiac metabolism as the final determining factor. 功能异常相关研究见 Journal of Cardiology 2008;52:67-78 * * * * * 在JCAD研究中，发现喜格迈治疗可以显著减少急性心肌梗死的发生。对照组发生急性致死性心肌梗死的例数为43，而喜格迈治疗组发生致死性心肌梗死的患者为19例，是对照组的一半, P0.01，组间具有统计学差异。这主要是由于喜格迈可以模拟缺血预适应，可以减少缺血对心肌的损伤，减少缺血所造成的致死性心肌梗死。