肠道杆菌和弧菌(医学课件).pptVIP

Systemic toxic symptoms Abdominal cramps, diarrhea, fever, and bloody stools  Prevention of fecal-oral transmission is the most effective control strategy. Dysentery is treated with antibiotics. But multiple drug resistance mediated by plasmids are common in many Shigella strains. Vaccines are not currently available. Control Salmonella 沙门菌属 Gram negative bacilli, with pili, no spore, no capsule (but with slime capsule) motile with flagella Non-fermentation of lactose antigenic structures: O, H and Vi antigens (More than 2000 serotypes based on antigenic difference) Morphology and identification Pathogenic factors Vi antigen: consisted of capsular polysaccharide. It resists phagocytosis and plays an important role during invasion of Salmonella. Endotoxin: fever, toxic syndrome, shock, enteric inflammation Enterotoxin: watery diarrhea Diseases Human and many different animals can be carried or infected with Salmonella . Salmonella can survive in gall bladder because of its bile resistance and establish chronic carriage. Diseases Enteric fever (typhoid fever) 肠热症 Food-poisoning 肠胃炎（食物中毒） Septicemia 败血症 Enteric fever / typhoid fever Enteric fever / typhoid fever is the most serious form of salmonella infection which only occurs in human. Carrying state of the microbes in human is common so that one carrier can cause a lot of spread. In untreated patients, the death rate is from 7% to 14%. Antibiotic therapy is essential, vaccines are not widely effective and not generally used. living storehouses and factories of disease and human culture tubes.  Typhoid Mary A healthy carrier of typhoid who by this time had already infected numerous people through her cooking…. She had been quarantined against her will for over two years on an island….. The microbe initially invades intestinal mucosal epithelium and propagate in the local. The microbe penetrates into the bloodstream to cause the first bacteremia 菌血症 with symptoms of fever, genera