培训课件_药动学.pptVIP

* * * * * The zero-order kinetics is also called as the saturation kinetics, by which a few drugs, such as ethanol, phenytoin and salicylate, have a linear elimination pattern (non-exponential or biexponential patterns), i.e. drug is removed at a constant rate that is independent of plasma concentrtation. * * * * * 5个半衰期规则 经过5个半衰期可达到稳态血药浓度! 大约经过5个半衰期药物从体内消除完毕!! 当改变药物剂量时，仍需经过5个半衰期才能达到新的稳态血药浓度 两种动力学过程的比较 一级动力学 零级动力学 消除规律 按恒比规律 按恒量规律 t1/2 t1/2恒定 t1/2受血药浓度影响，浓度高，t1/2延长 基本公式 Ct = C0e-K t t1/2 = 0.693/K Ct = C0-K t t1/2 = C0/2K 出现情况 是大多数药物消除形式 是少数药物消除形式 hrs Plasma concentr