肿瘤细胞是一个积累了不同基因突变的体细胞.pptVIP

* 原因：缺少核酸外切酶（exonuclease），不能切除紫外线诱发的胸腺嘧啶二聚体T-T。患者的非同源染色体之间常产生交联而导致易位、染色体畸变，产生许多对称的四射体。 患者外周血培养细胞有各种类型的，包括 The test for Fanconis Anemia is done to detect DNA repair mechanism defects in patients by culturing their blood along with blood from a sex - matched control using two different alkylating agents which can cause breaks in chromosomes. This metaphase spread shows an example of radial formations (red arrows). This is commonly seen in individuals with Fanconis Anemia, and is one of the most reliable indications of the presence of the disease. Normal Tumor Monoclonal origin hypothes