中草藥烟用添加剂的止咳化痰的研究.docVIP

PAGE PAGE 1 中草药烟用添加剂止咳、祛痰作用的研究 刘绍华，李志华，胡志忠，白家峰，邹克兴，黄泰松 广西中烟工业有限责任公司 技术中心，广西南宁市北湖南路28号 530001 编号“201106032 摘要 目的：研究中草药烟用添加剂的止咳、祛痰作用。方法：采用小白鼠氨水引咳法评价中草药烟用添加剂的止咳作用。采用小鼠气管段酚红法评价其祛痰作用。结果：中草药烟用添加剂30g/kg组小鼠的R值大于150%；中草药烟用添加剂30g/kg，15g/kg，7.5g/kg均可明显增加小鼠酚红排泌量，（与对照组比较 p0.05，p0.01）。结论：中草药烟用添加剂能够减轻氨水引咳法引起的小鼠咳嗽，增加小鼠气管酚红排出量，显示其具有显著的镇咳和祛痰作用。 关键词：罗汉果；添加剂；卷烟；止咳；祛痰 Studies on the Antitussive　and Expectorant Effects Of the Chinese Herbal Medical Tobacco Additive LIU Shao-hua, LI Zhi-hua ,HU Zhi-zhong, BAI Jia-feng, ZOU Ke-xing， HUANG Tai-song （Technical center of China Tobacco Guangxi Industrial Co. Ltd., No.28 The South of Beihu Rd, Nanning 530001 Abstract: Objective　To observe the antitussive and expectorant effects of the Chinese herbal medical tobacco additive. Methods The model of cough induced by ammonia liquor spray in mice was used to observe the antitussive effect; the model of phenol red in the trachea excretion in mice was used to observe the expectorant effect. Results The R value of mice in Chinese herbal medical tobacco additive 30g/kg group is over 150%; Chinese herbal medical tobacco additive 30g/kg ,15g/kg ,7.5g/kg could remarkably increase the phenol red output of trachea in mice (p0.05,P0.01 vs 作者简介：刘绍华(1962-)，博士后，广西中烟工业公司技术中心高级工程师，主要从事天然产物在卷烟中应用的研究。E-mail:lshaohua18@ 电话：0771-8098556. control). Conclusion The Chinese herbal medical tobacco additive could inhibit the cough induced by ammonia in mice and increase phenol red output of trachea in mice, which shows significant antitussive and expectorant effects. Key words: Siraitia grosvenori; Additive; Cigarette; Antitussive；? Expectorant 本研究的中草药烟用添加剂系以罗汉果为主要中药原料的提取物。罗汉果[Siraitia grosvenori (Swingle) C. Jeffrey exluet Z. Y. Zhang ]， 是广西桂北地区的著名特产，性凉味甘，无毒，具有润肺、滑肠、通便、保肝等功效，主要用于祛痰剂，在治疗肺炎、百日咳、慢性气管炎、咽喉炎、胃肠疾病、便秘等疗效显著，还有增强免疫的作用[1]。罗汉果苷(mogrosides)是罗汉果的甜味成分，主要包括罗汉果苷III～VI (mogroside-III～VI)、11-氧代-罗汉果苷V(11-oxo-mogrosides)和赛门苷I(siamenoside-I)。其中，罗汉果苷V是主要活性成分，其甜度约为蔗糖的350倍[2-3]。98%罗汉果苷有止咳、袪痰等作用[4]。罗汉果苷V还具有抑制肿