云南白药酊口服加外用抗炎作用的研究.docVIP

云南白药酊口服加外用的抗炎作用研究 张立群 ，闫俊岭1 ，张信岳2 ，李 钦2 ，陈爱君2 ，汪苾菡2 ，章琳莉2 （1. 云南白药集团股份有限公司云南白药研究院，云南 昆明 650032；2.浙江省医学科学院药物研究所，浙江 杭州310013） 摘要: 目的 研究云南白药酊口服加外用的抗炎作用。方法 采用佐剂性关节炎以及尿酸钠致关节痛大鼠模型探讨云南白药酊的抗炎作用。结果 云南白药酊口服加外用能明显抑制佐剂性关节炎大鼠致炎足的原发肿胀以及对侧足的继发肿胀，降低前足红肿计分；云南白药酊口服或口服加外用给药能明显抑制尿酸钠致大鼠关节炎肿胀，并明显降低该模型大鼠步态计分。结论 云南白药酊对佐剂性关节炎以及尿酸钠所致关节炎症均有拮抗作用，口服加外用显示较好的协同作用。 关键词：云南白药酊；口服加外用；抗炎；药效学 中图分类号：R285.5 文献标识码：A Study the Anti-inflammatory effects of Yunnanbaiyao Tincture Zhang Liqun1, Yan Junling1, Zhang Xinyue2, Li Qing2, Chen Aijun2, Wang Bihan2, Zhang Linli2 (1. Academe of Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., Kunming Yunnan 650032; Institute of Medicine, 2. Zhejiang Academy of Medical Sciences, Hangzhou Zhejiang 310013) Abstract: Objective To investigate the Anti-inflammatory effects of orally or topical plus intragastric administration of Yunnanbaiyao tincture in rats. Methods The anti-inflammatory effect of Yunnanbaiyao tincture was investigated not only on rats model of adjuvant arthritis induced by Freunds complete adjuvant, but also on joint pain caused by uric acid sodium. Results The Yunnanbaiyao tincture were given by external or intragastric administration could significantly alleviate the primary swelling of on foot subjected to being injected Freunds complete adjuvant, and also could extenuate secondary swelling on contralateral foot. At the same time, it could reduce to the swelling score of the forefoot. In rats model of joint pain caused by uric acid sodium, orally or topical plus intragastric administration of Yunnanbaiyao tincture could significantly inhibit the swelling of rat arthritis, and significantly reduce the gait score about rats. Conclusion Intragastric or topical administration of Yunnanbaiyao tincture has obvious anti-inflammatory not only on rats model of adjuvant arthritis induced by Freunds complete adjuvant, but also on joint pain caused by uric acid sodium. Topical plus intragastric administration of Yunnanbaiyao tincture shows a certain synergistic