培训课件_治疗心力衰竭的药物.pptVIP

* (2) Increase the cardiac output in patients with CHF. (增加心衰病人的CO) 强心苷 force of contraction (收缩力) ↑ Peripheral resistance (外阻) ↑ CO normal heart CO CO不变 Vasoconstriction血管收缩 * 强心苷 CO↑ Sympathetic activity (交感活性) ↓ force of contraction (收缩力) ↑ CO↑ Vasodilation 血管扩张 Peripheral resistance (外阻) ↓ failing heart CO↑ Vasoconstriction血管收缩 * (3) Decrease the myocardial oxygen consumption (降低衰竭心脏的耗氧量) 衰竭心脏 强心苷 儿茶酚胺类 心肌收缩力 ↓ ↑ ↑ HR ↑ ↓ ↑ 室壁张力 ↑ ↓ 总耗氧量 拟肾上腺素药如Adr or Isop能否治疗CHF？ Question * mechanism of action ㈠ Na+-K+-ATPase → Na+-K+exchange↓ → intracellular [Na+]