盐酸戊乙奎醚治慢性肺心病急性发作期的临床研究.docVIP

盐酸戊乙奎醚治疗慢性肺心病急性发作期的临床研究 程立新 苏春花 张伟丹 王世军 (山东省德州市人民医院急诊科 德州253014） 【摘要】 目的 研究盐酸戊乙奎醚在慢性肺源性心脏病急性发作期治疗中的疗效。方法 265例慢性肺心病急性发作期病人随机分为2组：Ⅰ 组：给予氧疗、平喘、祛痰、抗感染、抗凝、强心利尿、降低心脏负荷及糖皮质激素等常规治疗。Ⅱ 组：在常规治疗治疗基础上加用盐酸戊乙奎醚治疗。对2组临床疗效进行对比分析。结果 显效率：Ⅰ组29.8%，Ⅱ组72.4%(p0.01)；总有效率:Ⅰ组61.8%，Ⅱ组93.3%,2组相比有显著性差异（p0.05)。住院总死亡率Ⅰ组19.8%，Ⅱ组5.2%（p0.05)。因呼吸衰竭死亡率：Ⅰ组16%，Ⅱ组3.73%（p0.01)。治疗后临床症状改善时间：Ⅱ组12±8.8小时，Ⅰ组30±7.5小时（p0.01）。结论 盐酸戊乙奎醚用于慢性肺源性心脏病急性发作期的综合疗效明显优于传统疗法。 【关键词】 慢性肺源性心脏病；呼吸衰竭； 盐酸戊乙奎醚 【中图分类号】 【文献标识码】 【文章编号】 Studying of Penehyclidine Hydrochloride on Patients with Acute onset of Chronic Pulmonary Heart Disease. CHENG Li-xin, SU Chun-hua, ZHANG Wei-dan et al. Department of emergency,People＇s Hospital of DeZhou City(DeZhou 253014,china) 【Abstract】 Objective To evaluate the clinical effects of routine and Penehyclidine hydrochloride on patients with acute onset of chronic pulmonary heart disease. Methods 265 cases of acute onset of chronic pulmonary heart disease were randomly divided into two groups.GroupⅠwas given routine therapy including oxygen-therapy, antispasmodics, antibiotics, anticoagulant, diuretics and cardiotonics, reduced heart load and renocortical steroid. GroupⅡ was added Penehyclidine hydrochloride besides routine therapy.The clinical effects were compared among the groups. Results The evident effective rates were 29.8% in groupⅠ, and 72.4% in group Ⅱ. The evident effective rates of groupⅡ were significantly higher than that of groupⅠ(p0.01). The overall effective rates were 61.8% in groupⅠ,and 93.3% in group Ⅱ (p0.05). The hospitalized mortality rates were 19.8% in group Ⅰ,and 5.2% in groupⅡ(p0.01).The time of clinical improvement was 30±7.5 hours in group Ⅰ, and 12±8.8 hours in group Ⅱ(p0.01).Conclusion The comprehensive effect of combined routine therapy, Penehyclidine Hydrochloride are superior to the conventional therapy on patients with acute onset of chronic pulmonary heart disease. 【Key wards】Chronic Pulmonary Heart Disease ；respiratory failure；Penehyc