移植免疫2013重点.ppt

中南大学湘雅医学院免疫教研室田 伟 博士， 教授 Allografts: transplants from a genetically unrelated donor of the same species. Allogeneic transplantation: the last resort for the treatment of chronic organ failure. the major complication post-transplantation is rejection. Rejection occurs in almost all transplant recipients, to varying degrees. Antigen independent mechanisms Peritransplant ischemia Mechanical trauma Reperfusion injury Peritransplant injury induces chemokines that increase inflammation and immunity Content Immunological mechanism in allogeneic graft rejection Types of transplant rejection