移植免疫进展重点.ppt

Immunosuppresive Therapy Immunosuppresive Therapy Downsides Must be maintained for life Toxicity Susceptibility to infections Susceptibility to tumors （四）诱导免疫耐受 建立中枢嵌合体 移植前输血 胸腺内注射供者抗原 阻断共刺激信号 移植物的预处理 免疫隔离 Blood transfusion and graft survival 阻断共刺激信号 Removal of T cells from marrow graft Magnet Magnetic antibodies 移植存在的问题 排斥反应 移植物短缺 原发疾病对移植物的损坏 免疫抑制手段的副作用 花费高昂 Hoops for Xenotransplantation +PERVs * Common manifestations of GVH reaction are diarrhea, erythema, weight loss, malaise, fever, joint pains, etc. and ultimately death. * PROCEDURES TO ENHANCE GRAFT SURVIVAL In clinical p