王慧娟-肺鳞癌免疫治疗进展.pptVIP

POPLAR: 组织学分层的OS POPLAR : ORR和OS Median OS, Mos (Range) TC3 or IC3 (n = 47) TC2/3 or IC2/3 (n = 105) TC or IC1/2/3 (n = 195) TC0 or IC0 (n = 92) Atezolizumab 15.5 (9.8-NE) 15.1 (8.4-NE) 11.5 (11.0-NE) 9.7 (8.6-12.0) Docetaxel 11.1 (6.4-14) 7.4 ( 6.0-12.5) 9.2 (7.3-12.8) 9.7 (6.7-11.4) HR (95% CI)P value 0.49 (0.22-1.07) 0.068 0.54 (0.33-0.89) 0.014 0.63 (0.40-0.85) 0.005 1.12 (0.64-1.93) 0.871 TC3 or IC3 TC1/2/3 or IC1/2/3 TC0 and IC0 TC2/3 or IC2/3 ITT Spira AI, et al. ASCO 2015. Abstract 8010. Vansteenkiste J, et al. ESMO 2015. Abstract LBA14. 38 40 30 20 10 0 ORR (%) Atezolizumab (n