NF-kB 和RA的究进展.docVIP

类风湿性关节炎中的核因子-κB 〔摘要〕核因子-κB是Rel家族的二聚转录因子,是免疫、炎症和应激反应的主要调控因子，参与大部分类风湿性关节炎的病理生理过程。现就核因子-κB与类风湿性关节炎的关系，以及类风湿性关节炎治疗方法的研究进展作简要的综述。 〔关键词〕核因子-κB，类风湿性关节炎 Nuclear factor – kappaB is a potent proin?ammatory cytokine in rheumatoid arthritis . 〔Abstract〕Nuclear factor – kappaB is a dimer transcription factor from Rel family and a major regulatory factor of the immunity, inflammation and stress reaction.It is involved in the main patho-and physio- procedure of rheumatoid arthritis.Herein,we review research on the relationship of nuclear factor –kappaB with rheumatoid arthritis,and the tr