Nutrition nd Colonic Health.docVIP

Nutrition and Colonic Health: The Critical Role of the Microbiota Stephen J.D. OKeefe, MD, MSc, FRCP Curr Opin Gastroenterol. 2008;24(1):51-58. Abstract and Introduction Abstract Purpose of review: To highlight mechanisms whereby diet affects colonic function and disease patterns.Recent findings: Topical nutrients are preferentially used by the gut mucosa to maintain structure and function. With the colon, topical nutrients are generated by the colonic microbiota to maintain mucosal health. Most importantly, short chain fatty acids control proliferation and differentiation, thereby reducing