reading exrcise 13.docVIP

READING EXERCISES 13 Acute Leukemia Definition Normal hematopoiesis requires tightly regulated proliferation and differentiation of pluripotent hematopoietic stem cells to become mature peripheral blood cells. Acute leukemia is the result of a malignant event, or events, occurring in an early hematopoietic precursor. Instead of proliferating and differentiating normally, the affected cell gives rise to progeny that fail to differentiate and instead continue to proliferate in an uncontrolled fashion. As a result, immature myeloid cells (in acute myelogenous leukemia) or lymphoid cells (in ac