HLA与疾病_培训课件.pptVIP

HLA 与 疾 病 近年免疫遗传学表明免疫与遗传有关，基因表达量的异常可以引起免疫功能的紊乱，导致免疫性疾病的发生，这为探讨免疫性疾病的发病机制开辟了新途径。 遗传多态性是药物反应中个体差异的遗传基础，通过识别特定的多态基因型与药物疗效及毒性的关系，可为个体化治疗提供依据 Drugs and ADRs (药物与急性皮肤反应) Drug(药物) Treatment(治疗) ADR HLA Allele associated to ADR Carbamazepine 痛痉宁 (镇痛,抗惊厥药) Epileptic seizures, neuralgia and other neural diseases 癫间,神经痛,神经疾病 SJS/TEN* HLA-B*1502 Allopurinol 别嘌呤醇(治痛风) Gout (痛风病) SJS/TEN* HLA-B*5801 SJS:Steven-Johnson综合症 TEN:毒性皮肤坏死 (Toxic Epidermal Necrolysis) HLA-B*1502 Prevalent in Asia The risk of SJS/TEN is estimated to be about 1 to 6 per 10,000 new users in countries with mainly Caucasian population