胃肠病药物治疗_培训课件.pptVIP

Loperamide A synthetic antidiarrheal narcotic analogue, agonist activity on gut-associated mu-opiate receptor Antisecretory and prolonging gut transit Decreasing water electrolytes absorbance from gut lumen Loperamide Indication Chronic diarrhea associated with IBD Adjunct Tx. of nondysentric diarrhea Postvahotomy diarrhea Dosage 4~8 mg/day, not excess 16 mg per day Loperamide Side Effects Constipation, abdominal pain, distention, bloating, nausea and vomiting Central Nervous system depression: dorwsiness, dizziness, and fatigue often seen in high dose Loperamide Pearls Pitfalls Naloxone is