从预防低血糖的重要性看DPP4i的应.pptx

从预防低血糖的重要性 看DPP4i的应用价值1234低血糖风险不容忽视达标与低血糖矛盾：不可调和还是对立统一？追溯矛盾的根源，探寻理想治疗方案DPP4抑制剂在理想降糖治疗中的应用价值目录Alert value for hypoglycemia:PG ≤ 70 mg/dL ( ≤ 3.9 mmol/L)Severe hypoglycemiaRequire assistance; PG may not be available during an event, but neurological recovery following the PG return to normal is considered sufficient evidence that the event was induced by a low PG.Documented symptomatic hypoglycemiaTypical hypoglycemia symptoms are accompaniedby measured PG ≤ 70 mg/dL (≤3.9 mmol/L).Asymptomatic hypoglycemiaNot accompanied by typical hypoglycemia symptoms but with by measured PG ≤ 70 mg/dL (≤3.9 mmol/L).Probable symptomatic hypoglycemiaTypical hypoglycemia symptoms not accompaniedby PG determination but likely caused by PG ≤ 70 mg/dL (≤3.9 mmol/L).Pseudo-hypoglycemiaReport of typical hypoglycemia symptoms with PG70 mg/dL (3.9 mmol/L) but approaching hypoglycemia threshold.PG: plasma glucoseSeaquist, E.R., et al., Diabetes Care, 2013. 36(5): p. 1384-95.中华医学会糖尿病学分会, 中国2型糖尿病防治指南(征求意见稿), 2013.低血糖分类* These values indicate number of events (instead of number of individuals) and values given in parentheses are event rates per 100 person-years; these values were not included in the calculation of the combined proportion Δ Any hypoglycaemic episodes refer to those with symptoms compatible with hypoglycaemia. Serious episodes are those that required hospital admission Ω Hypoglycaemia defined as blood glucose2.8 mmol/l or the presence of typical signs and symptoms of hypoglycaemia without another apparent cause. Patients with transient dysfunction of the central nervous system, who were unable to treat themselves, requiring help from another person, were said to have serious hypoglycaemia. Also note that both treatment groups lost weight, expressed as negative weight gain δ Any episodes are those hypoglycaemic episodes with symptoms, and serious episodes are life threatening, or those that cause hospitalization, disability, death or incapacity ^ Any hypoglycaemic event refe