BeyondCoexpressionGeneNetworkInference课程.pptVIP

Beyond Co-expression:Gene Network Inference Patrik D’haeseleer Harvard University http://~patrik Beyond Co-expression Clustering approaches rely on co-expression of genes under different conditions Assumes co-expression is caused by co-regulation We would like to do better than that: Causal inference What is regulating what? Gene Network Inference Overview Modeling Issues: Level of biochemical detail Boolean or continuous? Deterministic or stochastic? Spatial or non-spatial? Data Requirements Linear Models Nonlinear models Conclusions Level of Biochemical Detail Detailed models require lots