纤维连结蛋白在肾间质纤维化大鼠肾组织中的表达课题.doc

纤维连结蛋白在肾间质纤维化大鼠肾组织中的表达及意义 程红新1 杨晓萍1 蒋雅红3 林智峰1赵瑾2 陶林2 新疆石河子大学医学院，1第一附属医院肾病科，2病理科，3第三附属医院医务部，新疆维吾尔自治区石河子市 832008 摘要： 背景：纤维连结蛋白(Fibronectin，Fn肾间质纤维化（ RIF）β1（TGF-β1）的表达。 结果与结论：与正常组及对照组比较，梗阻时间越长，肾小管间质损害程度越重，纤维化越明显。造模后1 d大鼠肾脏组织FN、MMP-9表达水平即出现上调，造模后3d，TGF-β1表达水平出现上调，并均于第14天达最高水平，与同期正常组、对照组相比，差异有显著性意义（P 0.05）单侧输尿管梗阻β1；肾间质纤维化 The expression and its siginificance of Fibronectin in Rats at kidney with Renal Interstitial Fibrosis CHENG Hong-xin ,YANG Xiao-ping, ZHAO Jin，TAO Lin (Department of Nephrology , the First Affiliated Hospital of Shihezi Medical University, Xinjiang 832000, China) Abstract BACKGROUND: The increasing of the expression of Fibronectin played the important role in the process of the renal interstitial fibrosis . OBJECTIVE: To investigate the expression and the effects of fibronectin (FN) in Rats at kidney with renal interstitial fibrosis(RIF).