HR与尿微量白蛋白相关临床研究进展-综述20151107.docVIP

高血压视网膜病变与尿微量白蛋白相关临床研究进展 杨梦璐，李骏，杨柳 作者单位：北京大学第一医院眼科，视觉损伤与修复教育部重点实验室 通信作者：杨柳 Email：lucy02114@163.com 摘要：Hypertensive retinopathy, HR）。目前没有一个独立指标可预测高血压视网膜病变的发生。同样作为终末枝血管，肾脏血管在高血压病发展过程中也经常受累，大量研究验证了高血压视网膜病变与高血压病肾损害的相关性。尿微量白蛋白(Microalbuminuria, MA)肾脏疾病的独立危险因素，本文了近年来有关高血压视网膜病变、及尿微量白蛋白的相关性研究，探讨 关键词：高血压视网膜病变尿微量白蛋白风险预测 Current Clinical Research Progress on Hypertensive Retinopathy and Microalbuminuria Meng-lu YANG, Jun LI, Liu YANG Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 10034, China Corresponding Author: Liu YANG, Email: lucy02114@163.com Abstract: Hypertension is a common cardiovascular disease and retina is likely to be involved when hypertension occurs. The usual features of hypertensive retinopathy are arteriolar attenuation, Gunn’s or Salus’ sign, superficial flame shaped hemorrhage, lipid exudates and macular edema. So far there is no reliable index predicting the occurrence of hypertensive retinopathy. Similar to retinal vessel as terminal vessel, the renal vessel is another main target for hypertension. A large number of researches proved the relation between the two target organs in hypertensive individuals. Microalbuminuria is an independent risk factor of chronic kidney dysfunction in general population and it is also the risk factor of cardiovascular disease. In this review we collected recent studies on hypertensive retinopathy, hypertensive kidney lesion and their relation with microalbuminuria, in order to discuss the value and relevance of microalbuminuria in detecting hypertensive retinopathy. Key Words: Hypertensive retinopathy; Hypertensive kidney lesion; Microalbuminuria; Risk forecast 引言： [1,2]。视网膜血管是全身唯一直视下可观察的血管，尿微量白蛋白(Microalbuminuria, MA)是普通人群的肾脏疾病的独立危险因素，目前由于测量24h微量白蛋白过程过于繁琐，24h尿样不易保存，临床及研究多用尿白蛋白-肌酐比率（urinary albumin/creatinine ratio ，uACR）替代24h尿微量白蛋白。尿微量白蛋白可以反各靶器官功能损害，如肾脏[]、大血管[]等，目前有大量文献支持MA与血压关系，即使MA仍处于正常值，对高血压患者结局的预测也有重要意义。本文近年来有关高血压视网