固有免疫gaobo140925精品.ppt

（1）RIG-1和MDA-5是胞质溶胶中识别病毒双链RNA的感知元件。（3)而且RLR本身是干扰素诱导蛋白。基本结构N端为效应结构域CARD，C端为RNA解旋酶结构域，与之发生作用的衔接蛋白IPS1同型互作，分别通过核因子和干扰素调节因子激活促炎症细胞因子和I型干扰素Recognition of microbial RNA and DNA by cytoplasmic pattern recognition receptors. RIG-I and MDA5 recognize 5’-triphosphate ssRNA and dsRNA from RNA viruses and trigger signaling cascades via a CARD-containing adaptor molecule, IPS-1. IPS-1 induces the expression of genes for type I interferons and pro-inflammatory cytokines by activating transcription factors of the IRF and NFκB families. The role of LGP2 in RNA virus recognition is unclear and LGP2 has been p