09 病毒学virus巴斯德研究所课件.pptVIP

Pinto Lamb, J Biol Chem. 2005 FluA M2, Flu BM2 Flu Amantadine stucks in M2 Flu Hay et al. EMBO J. 4:3021 -3024, 1985 Amino acid mutation of AD resistant M2 Hay et al. EMBO J. 4:3021 -3024, 1985 Amino acid mutation of AD resistant M2 2 Flu Anti-viral drugs Anti-viral polymerase Anti-viral protease Anti-viral ion channel Anti-viral neuraminidase Anti-viral integrase oseltamivir Relenza Tamiflu The active site of influenza A neuraminidase Flu Structure of GG167 (Zanamivir) Flu Combination of anti-virals HIV: HAART HCV: interferon + ribavirin Targ