免疫检查点资料.pptVIP

* Immune checkpoint blockade: Releasing the brake towards hematological malignancies 2016.9.1 1、Introduction 2、Biology of immune checkpoints 3、Checkpoints deregulation in hematological malignancies 4、Clinical impact of drugs blocking immune checkpoints in hematological malignancies 5、Opportunities for combination approaches 6、Conclusions Contents Introduction Malignant cells provide neoantigens generated by vast tumor- specific mutation as potential targets for immune destruction by host immunosurveillance. Checkpoints are a specific subset of negative regulators that