复方苦参注射液对乳腺癌化疗毒副作用的影响.docVIP

复方苦参注射液对乳腺癌化疗毒副作用的影响 　　[摘要] 目的 观察复方苦参注射液对乳腺癌术后化疗患者毒副作用的影响。 方法 将64例乳腺癌患者随机分为两组：复方苦参注射液加化疗组作为观察组，化疗组作为对照组，每组32例。治疗6个周期后观察两组患者的症状改善情况、不良反应、近期疗效以及生活质量。 结果 观察组临床症状改善率为81.21%，对照组临床症状改善率为53.14%；观察组与对照组的毒副反应情况差异显著；观察组治疗后疗效与稳定率分别为92.53%和62.83%与对照组差异显著。 结论 复方苦参注射液能够缓解乳腺癌患者术后化疗的临床症状，提高患者免疫力，改善其生活质量，临床上值得推广使用。 　　[关键词] 复方苦参注射液；乳腺癌；化学疗法；毒副作用 　　[中图分类号] R737.9 [文献标识码] B [文章编号] 2095-0616（2014）13-67-03 　　[Abstract] Objective To observe the effects of compound matrine injection on the toxic and side effects in chemotherapy of breast cancer. Methods 64 patients with breast cancer were randomly divided into two groups， 32 cases in each group. The control group received chemical treatment and routine post operative recovery treatment， while the observation group was added with compound matrine injection based on the treatment of the control group. The improvement of symptoms， recent therapeutic effects， incidences of adverse reactions and quality of life before and after treatment were observed. Results The clinical symptoms improved after treatment was 81.21% in the control group after treatment to improve the rate of 53.14%； adverse reactions observed group and the control group with significant difference； observation group improved quality of life and stability rates were 92.53% and 62.83% and significant different with the control group. Conclusion Compound matrine injection， with conspicuous recent therapeutic effects， can significantly relieve symptoms of chemotherapy of breast cancer， improve patients quality of life， so it is worthy of being popularized and applied in clinical chemotherapy. 　　[Key words] Compound matrine injection； Breast cancer； Chemotherapy； Toxic and side effects 　　乳腺癌作为最为常见的恶性肿瘤之一，近年来随着乳腺癌发病率不断攀升现已高居女性恶性肿瘤发病率的首位[1]，依据我们目前的医学发展水平还不能够很清楚的解释其发生、发展及转归过程。目前乳腺癌的治疗手段是以手术为主， 辅以放化疗、内分泌治疗及生物靶向等的综合治疗[2-3]。中医药用于术后干预有着其独到的优势，其不仅能够调动患者免疫系统来预防肿瘤的复发和转移，且有助于减缓放化疗所产生的毒副作用。 　　复方苦参注射液主要活性成分包括苦参碱和氧化苦参碱等，主要功效为清热燥湿解毒，并具有一定的扶正作用，为现今临床常用的注射剂之一[4-5]。本研究采用中药复方苦参注射液联合化学疗法治疗恶