USE OF CALCIUM PHOSPHATE BONE CEMENT FOR …对.PPTVIP

 USE OF CALCIUM PHOSPHATE BONE CEMENT FOR FRACTURE FIXATIONS IN OSTEOPOROTIC PATIENTS  By: Sindhu Gowri Agenda Bone Composition Osteoporosis Market Analysis Bone Replacement Options Calcium Phosphate bone cement Manufacturing method Fracture Fixations Clinical Trials Future Directions Bone composition Bone is the main support system of the body. It is a dynamic tissue which is replaced everyday in our lives. Bone is made up of minerals such as calcium, phosphorous, sodium, potassium, chloride, fluoride etc. The calcium content in bone is 34.8 wt%, and in hydroxyapatite is 39.6 wt%. Other important substances found in the human bone are water (8- 10 wt %), and collagen (35 wt %).  Osteoporosis “A skeletal disorder characterized by compromised bone strength (bone density and bone quality) predisposing to an increased risk of fracture” – WHO Factors: age, gender, family history, diet and exercise. Measurement and Prediction: Bone Mineral Density (BMD) T-score value: if the BMD is -2.5 SD. Osteoporosis…cont Weak and porous structure: The decrease in the bone mass. Imbalance in the production and usage of calcium, therefore the bone voids are not filled in completely. This leads to instability in fixing metal hardware such as bone screws and plates resulting in poor performance of the implants. Source: Bone and Joint Decade /eLecture/1609/GMaalouf.html Osteoporosis in women Osteoporosis is gender related. In women after menopause estrogen level decreases resulting in decreased production of minerals and bone. Women at the age of 35 are at the peak BMD. BMD decreases significantly during menopause (1-5 % decrease in bone mass) Further decrease leads to osteoporosis. /osteoporosis/osteo_diagnose.asp Market Analysis (U.S) Currently there are 2 million fractures annually due to osteoporosis in the U.S. The estimated medical care costs for osteoporotic patients is 14 billion $. By 2050 the expected medical care costs for osteopo