第抗心肌缺血药物.pptVIP

抗心绞痛药 Antianginal Agents 药学院 药理教研室 吕俊华教授 Understand the pharmacological effects, therapeutic application and major adverse reactions of antianginal agents; Beware of the classification of the drugs; Understand the mechanism of relief of symptoms of angina pectoris by antianginal agents. What is Angina pectoris 心绞痛? 缺血性心肌病的常见症状 典型症状： 突然发生的胸骨后紧缩或压榨性疼痛 向左前胸区和左上肢放射 发作原因：心肌氧的供需平衡失调 急剧、暂时缺血缺氧 乳酸，丙酮酸等代谢物↑ Determinants of myocardial oxygen  requirement and oxygen supply 缺血性心脏病 最常见病因冠状动脉粥样硬化性心脏病（冠心病） 粥样硬化引起狭窄和闭塞（95% ） 痉挛性收缩 血栓形成、斑块脱落、栓塞 O2的供需失去平衡 Types o