HistoryofMalignantLymphoma.ppt

History of Malignant Lymphoma ---- What ’s kind of road we have traced? Three stages of lymphoma cognition Morphology before 70’, 21st century Thomas Hodgkin published his paper,On some Morbid appearance of the Absorbent gland and the spleen, in 1832. Sir Samuel Wilks (1865), provided a more detailed and critical clinical and pathological description of the some disorder and acknowledged Hodgkins earlier contribution. The term “Hodgkin’s disease” was estabished. Greenfield (1878), among others, described characteristic giant cells in patients with HD primarily. Jackson Parker (1947) introduced The first histological classification of Hodgkins lymphoma (paragranuloma, granuloma and sarcoma). Conference held in Rye, New York in 1966 simplified the Lukes and Butler scheme into a four-part classification and expanded into its present version at conferences held in Ann Arbor, Michigan (1971), which further remodified by Costwolds in 1989. View of main classification of Hodgkin’s lymphoma The delineation of the Non-Hodgkins lymphomas Virchow (1845) and Bennett (1845) described the first cases of leukaemia. A probable case of acute leukaemia was published by Cohnheim (1865) under the descriptive term ‘pseudoleukaemia’. The follicular or nodular lymphomas were first clearly described by Brill et al (1925). Gall and Mallory (1942) introduced a lymphoma classification based on clinicopathologic criteria, which, for all its shortcomings, was the first systematic attempt to make order out of the chaotic NHL situation. Rappaport et al (1956) presented medicine with a lymphoma classification that could be applied easily and was prognostically useful. Two criteria were employed to differentiate lymphoma subtypes: the presence or absence of nodularity, and cell size (small, intermediate and large lymphoid cells). Lukes Collins (1974) established a new immnuological classification based on their knowledge about B-cell