AD的诊断标准新进展(陈璇)讲述.ppt

背 景 阿尔茨海默病 Alzheimer’s Disease 1907 Alois Alzheimer 老年人痴呆最常见形式 US：4.5 million (2000年) 13.2 million (2050年) 65岁：15% 85岁：50% 进展性 致命性 神经变性疾病 A β沉积 ？ 病 理 Footnote 2: Standard neuropsychological testing by a qualified neuropsychologist showing a significant decline (defined by statistically meaningful/reliable change in test scores) in a pattern of domains and at a rate consistent with AD-related change. Alternatively, clear-cut decline on a standardized bedside mental status examination could provide sufficient evidence for documented decline, provided the amount of decline meets lo