不同指征患者卵胞浆内单精子注射治疗后临床结局的比较.docVIP

不同指征患者卵胞浆内单精子注射治疗后临床结局的比较 　　解放军第一七四医院生殖中心，福建厦门 361003 　　[摘要] 目的 比较不同指征患者采用卵胞浆内单精子注射（ICSI）治疗后胚胎质量及临床结局。 方法 选择2009年1月～2011年12月解放军第一七四医院生殖中心采取ICSI方式助孕治疗的患者620例。按病因分为3组，A组150例为因无精子症原因行ICSI术的患者；B组416例为由于重度少弱精子症原因行ICSI术的患者；C组54例为由于受精障碍、低受精原因行ICSI术的患者。比较各组年龄、体重指数、不孕年限、卵子受精、胚胎卵裂、优质胚胎、临床妊娠和活产情况。 结果 ①三组患者年龄和体重指数差异有统计学意义（P 0.05）。②A组患者受精率[73.49%（1156/1573）]低于B、C组[76.25%（3008/3945）、78.47%（339/432）]，差异有统计学意义（P 0.05）。③A组妊娠率[62.0%（93/150）]和活产率[53.33%（80/150）]均显著高于B组[48.8%（203/416）、39.66%（165/416）]及C组[48.2%（26/54）、38.89%（21/54）]，差异均有统计学意义（P 0.05）。 结论 不同指征患者ICSI术后导致了受精情况的显著差异，但受精后各组之间的胚胎情况相似，女性年龄是影响临床结局的重要因素。 　　[关键词] 无精子症；重度少弱精子症；受精障碍；ICSI术 　　[中图分类号] R698 [文献标识码] A [文章编号] 1673-7210（2013）11（b）-0051-03 　　Clinical outcome analysis in ICSI patients with different indications 　　LIU Qiaobin JI Hong CHEN Yuanyuan REN Jianzhi 　　Department of Reproductive Medicine Center， 174th Hospital of PLA， Fujian Province， Xiamen 361003， China 　　[Abstract] Objective To compare the embryo quality and clinical outcome between patients of different indications with intracytoplasmic sperm injection. Methods 620 cases with assisted reproduction of ICSI in Department of Reproductive Medicine Center， 174th Hospital of PLA from January 2009 to December 2011 were selected and divided into 3 groups according to pathogenesis. 150 cases with severe azoospermatism of ICSI were distributed to group A； 416 cases with oligoasthenozoospermia of ICSI were assigned to group B； 54 cases with fertilization obstacles or low fertilization reason of ICSI distributed to group C. The age， body mass index， duration of infertility， fertilization rate， cleavage rate， good-quality embryo rate， clinical pregnant rate and live birth rate were observed. Results ①The differences of age and BMI among the 3 groups were statistically significant （P 0.05）. ②Fertility rate of group A [73.49% （1156/1573）] was lower than that of group B and group C [76.25% （3008/3945）， 78.47% （339/432）]， the differences were statistically signif