3.代谢与代谢的调控课件.pptVIP

Nutrient Deprivation Signals to p53 Vousden KH and Ryan KM. Nat Rev Cancer. 2009 Suppression of ChREBP Does not Activate AMPK Murphy, Biochemical Journal 2009 Overview of Mitochondrial ROS Production Increased ROS Level and Decreased Cellular Glutathione Level in ChREBP-deficient Cells Compared with Control Cells (HCT116 Cells) Antioxidant N-acetylcysteine (NAC) Reduces ChREBP Knockdown-induced p53 Activation (HCT116 Cells) Suppression of ChREBP Leads to a p53-dependent Reduction in Tumor Growth ChREBP is highly expressed in liver and colorectal cancer cells and critical for cancer cell pro