消化道息肉性病变-2010-3_图文.pptVIP

* Aberrant Crypt Foci. Left, methylene blue stained colonic mucosal sheet viewed under dissecting microscope. Crypt lumens are viewed on end, and appear as white spots. Aberrant crypt foci (arrows) have dilated diameters, increased staining, and slit-like lumens. Right, histologic examination of these aberrant crypt foci reveals dysplasia. These tiny microscopic adenomas are associated with bi-allelic inactivation of the APC gene * In this portion of the adenomatous polyp the dysplastic changes are sharply segregated from the normal goblet cells. * Microscopic appearance of villoglandular poly