Dose-response relationship.pptVIP

Chapter 6 Drug Toxicity Adverse drug reactions Paracelsus, a Swiss physician ( 1493-1541), proposed dose-toxicity relationship“all substances are poisons; there is none which is not a poison. The right dose differentiates a poison and remedy” Dose-related and Non-dose related genetic makeup, age, underlying pathology, status of immune system. DOSE similar to drug‘s effectiviness , drug’s toxicity e.g. lethality (mortality) also shows dose-response relationship, typical S-shape curve. LD50 (the dosage of a substance that kills 50% of the animals over a set period of time following an acute