[药理学]药物代谢动力学范本.ppt

G protein-linked receptors Tyrosine-kinase receptors Ion channel receptors Intracellular receptors Second messengers Type of receptors （一）G蛋白偶联R （二）配体门控离子通道型R （三）酪氨酸激酶R： （四）细胞内R： （五）其他酶类R：心房肽-R Two benefits of a signal-transduction pathway 1. Signal amplification 2. Signal specificity Signal amplification Amplification Amplification Amplification No amplification No amplification Receptor G-protein Adenylyl cyclase Cyclic cAMP Protein kinases Phosphates tranferred to target proteins Results in a tremendous increase in the potency of the initial signal permits precise contro