7++RNA加工例析.pptVIP

选择性剪接的调节通过激活子和抑制子实现 The regulating sequences : exonic (or intronic) splicing enhancers (ESE or ISE) or silencers (ESS and ISS). The former enhance and the latter repress splicing. Proteins that regulate splicing bind to these specific sites for their action SR proteins binding to enhancers act as activators. (1) One domain is the RNA-recognition motif (RRM) (2) The other domain is RS domain rich in arginine and serine. This domain mediates interactions between the SR proteins and proteins within the splicing machinery. hnRNPs binds RNA and act as repressors Most silencers are recognized by