CaOZnO抗菌材料的制备及其性能的初步研究解析.doc

CaO/ZnO抗菌材料的制备及其性能的初步研究 王丽丽1 孙源卿2 张颖丽1 孙宏晨3 林权2 于维先3 李祥伟*1 [摘要] 目的 制备CaO/ZnO核-壳结构纳米球材料，探讨其抑菌性和理化性能。方法 采用液相沉淀法制备CaO/ZnO核-壳结构纳米球，利用扫描电镜（SEM）、透射电镜(TEM)和离子体发射光谱仪(ICP)等对其进行表征；将该材料与丁香油酚调拌成糊剂，测定其成膜性能、流动性、固化、钙离子释放及pH值变化等；通过琼脂扩散法检测该糊剂对变形链球菌（Streptococcus mutans）、粪肠球菌（Enterococcus faecalis）、大肠杆菌（Escherichia coli）和金黄色葡萄球菌（Staphylococcus aureus）的抑制情况。结果 成功制备CaO/ZnO核-壳结构纳米材料，颗粒接近球形，粒径为80-90nm，具有核-壳结构；CaO/ZnO-丁香油糊剂pH值和钙离子累积释放量随时间增加而递增，流动性为24.22㎜/10min，成膜性为0.03μm/10min，符合ISO6876中根管封闭剂标准，与iRoot SP及氧化锌-丁香油糊剂相比，该糊剂具有更强的抑菌性（p﹤0.01）。结论 CaO/ZnO核-壳结构纳米球材料具有优良的抗菌性和理化性能。 [关键词] CaO；ZnO；核-壳结构；纳米材料；抑菌性 Synthesis and Preliminary Study on the Properties of CaO/ZnO Core-Shell Antibacterial Materials. WANG Li-li, SUN Yuan-qing, ZHANG Ying-li, SUN Hong-chen, LIN Quan, YU Wei-xian, LI Xiang-wei.1. Department of Endodontics, School and Hospital of Stomatology, Jilin University; 2. State Key Laboratory of Supramolecular Structure and Materials; 3. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling.Changchun 130021 [Abstract] Objective: The aim of the present study was to fabricate CaO/ZnO core-shell nanoparticles which possess antibacterial properties and investigate its physicochemical properties. Methods: The CaO/ZnO core-shell nanoparticles were prepared via precipitation method and characterized by transmission electron microscopy(TEM), scanning electron microscope(SEM) and inductive coupled 基金项目：吉林省科技发展计划项目（20140204018SF） 作者单位：1 吉林大学口腔医学院牙体牙髓病科；2 吉林大学超分子结构与材料国家重点实验室； 3 吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021 *通讯作者：李祥伟，电子信箱：lixiangwei@126.com Tel：0431plasma emission spectrometer(ICP). The film thickness, flow rate, solidification, pH, and calcium ion release from prepared samples which composed of eugenol and nanoparticles were examined. Antibacterial activities against Streptococcus mutans, Enterococcus faecalis, Escherichia coli and Staphylococcus aureus were evaluated by agar diffusion test (ADT). Results: CaO/ZnO c