酶法光学化合物合成(实验资料).docVIP

酶法光学化合物合成（实验） In modem synthetic organic chemistry, it is often necessary to use optically pure starting materials to prepare a target molecule, such as a drug, in enantiomerically pure form. However, reduction, [H], of a prochiral ketone 13, which bears two different alkyl or aryl residues on the carbonyl carbon atom, by catalytic hydrogenation or with hydride reducing agents such as sodium borohydride or lithium aluminum hydride gives equal amounts of the chiral alcohol 14 and its enantiomer ent-14(see as follows). This racemate produced because these achiral reducing reagents attack both f