AnimalModelPKPDAToolforDrugDevelopment.pptVIP

Animal Model PK/PD: A Tool for Drug Development David Andes, MD University of Wisconsin Madison, WI USA Pharmacokinetics The Primary Animal Model Pharmacodynamic Questions Predictive PD Parameter – What PK characteristic do I optimize? Magnitude of PD Parameter – How much drug do I need? PD Magnitude Variables – What factors impact how much drug I need? Study PD Correlation in humans – Can this help predict outcome in clinical disease? Mathematical Analysis of Dose-Response Data from Animal Models after 24 Hours of Therapy Nonlinear regression and Hill equation to estimate Emax (diffe