AProportionalOddsModelwithTime-varyingCovariates.ppt

A Proportional Odds Model with Time-varying Covariates Logistic Regression Model Logistic regression model when outcome is binary How do we extend the logistic regression model for time-to-event outcome? It depends on how we view the time progression Time Progression Extend Logistic Regression Model Renewal time progression Efron (1988, JASA) “Logistic-Regression, Survival Analysis and the Kaplan-Meier Curve” Suppose time is counted by months : # of patients at risk at the beginning of month : # of patients who die during month Assume that Extend Logistics Regression Model Cox proportional hazards model Interpretation of the regression parameter Instantaneous hazards ratio In terms of cumulative event rates Extend Logistics Regression Model So, why this happens? nonlinearity The fundamental issue is how we deal with different denominators of summing fractions What if we always count the cumulative events from time zero Common denominator Proportional Odds Model Logistic regression model Proportional odds model with time-varying covariates at time : Yang Prentice (1999, JASA) Proportional Odds Model Yang-Prentice PO Model Model closed under log-logisitic distributions Interpretation of regression parameter Without time-varying covariates Special case of the transformation models when the error term follows standard logistic distribution with unspecified transformation Rank estimation: Cheng, et al. (1995, Bmka) NPMLE Proportional Odds Model Transformation models with time-varying covariates Kosorok, et al. (2004, Ann Stat) is some frailty-induced Laplace transform Zeng Lin (2006, Bmka; 2007, JRSS-B) is some known transformation, e.g., Box-Cox transformation These models are not the Yang-Prentice models when the same error distributions/transformation would be chosen to obtain the proportional odds model without time-varying covariates Yang-Prentice Proportional Odds Model Yang Prentice (1999, JASA) Inference pro