丽珠胃三联根除hpylori感染疗效观察.docVIP

丽珠胃三联根除Hpylori感染疗效观察 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：胡友莹，胡联华，王克霞，张荣波，许礼发 【摘要】nbsp; 目的nbsp; 了解淮南地区慢性胃炎和消化性溃疡幽门螺杆菌（H.pylori）感染情况，探讨丽珠胃三联根除H.pylori疗效。方法nbsp; 在内镜下诊断为慢性胃炎和消化性溃疡的病人，于胃窦部距离幽门约3～5cm和胃体部大弯侧分别夹取2块胃粘膜组织，用于尿素酶检查、直接涂片镜检和病理组织学检查，前者与后两者任一阳性者为H.pylori感染阳性。结果nbsp; 慢性浅表性胃炎(CSG)H.pylori阳性率为81.6%，慢性萎缩性胃炎(CAG)为63%，胃溃疡(GU)为90.8%，十二指肠溃疡(DU)为93.3%。结论nbsp; 本地区慢性胃炎和消化性溃疡患者H.pylori 阳性率较高，丽珠胃三联治疗本地区H.pylori阳性的慢性胃炎和消化性溃疡，根除率高，疗效好，表明适宜用丽珠胃三联根除本地区H.pylori感染阳性患者。 nbsp;nbsp;nbsp; nbsp;nbsp;nbsp; 【关键词】nbsp; 幽门螺杆菌；丽珠胃三联；慢性胃炎；消化性溃疡 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; nbsp;nbsp;nbsp; 【Abstract】nbsp; Objectivenbsp; To investigate the effect of Livzon Weisanlian (bismuth agent 0.22g，b.i.d+tinidazole，0.5g，b.i.d+clarithromycin0.25g，b.i.d)for 7days for eradication of H.pylori and infection of patients suffering from chronic gastritis and peptic ulcer in Huainan area.Methodsnbsp; Four pieces of gastric mucosa were taken out by gastroscopy，two pieces of them from gastric antrum 3～5cm near pylori and the others from gastric body . All of them were detected for H.pylori and biopsy and smear .If both the former and the one of the later are all positive the patient was diagnosed with H.pylori infection.Resultsnbsp; The positive of CSG is 81.6% ， CAG is 63% ，GU is 90.8% and DU is 93.3%.Conclusionnbsp; The positive rate of patients suffering from chronic gastritis and peptic ulcer in Huainan area is high.The eradicative rate with Livzon Weisanlian is also high and it shows that Livzon Weisanlian is feasible to treat chronic gastritis and peptic ulcer. nbsp;nbsp;nbsp; nbsp;nbsp;nbsp; 【Key words】nbsp; H.(Helicobactor) pylori； Livzon Weisanlian； chronic gastritis； peptic ulcer nbsp;nbsp;nbsp; nbsp;nbsp;nbsp; 自1983年Marshall和Warren从慢性活动性胃炎患者胃粘膜活检标本中分离到幽门螺杆菌（H.pylori），并通过自身和自愿者的感染证实了H.pylori是慢性胃炎的致病菌后，人们又发现它还是消化性溃疡、胃粘膜组织相关性淋巴瘤、胃癌的致病因子。1994年世界卫生组织国际癌症研究机构（IARC）已经正式将其归为Ⅰ类生物性致癌因子。我国正常人群感染率为40%～60%［1］。 nbsp;nbsp;nbsp; nbsp;nbsp;nbsp; 我们曾经用粪便抗原（HpSA）快检卡调查过淮南地区城乡几所小学的