内皮素、胰高血糖素与肝硬化食管静脉曲张再出血关系的探讨.docVIP

内皮素、胰高血糖素与肝硬化食管静脉曲张再出血关系的探讨 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：杨根妹，彭雪莲，王晓春，林颖，张忠兵 【关键词】nbsp; 肝硬化；食管静脉曲张破裂再出血；,内皮素；胰高血糖素 nbsp;nbsp; ［摘要］nbsp; 目的nbsp; 探讨内皮素-1(ET-1)和胰高血糖素(GL)与肝硬化食管静脉曲张破裂再出血的关系。方法nbsp; 31例肝硬化食管静脉曲张破裂出血住院患者中，18例1周内再次出血(再出血组)，13例未再出血(未再出血组)。用放射免疫法分别测定两组患者在不同情况下血清内皮素和胰高血糖素浓度。结果nbsp; 再出血组患者的血清内皮素和胰高血糖素浓度［(101.28±22.88)pg/L和(209.89±32.50)pg/L］明显高于未再出血组［(60.38±5.78)pg/L和(172.92±16.39)pg/L］，Plt;0.05；再出血组中，肝功能ChildPugh C级两者［(108.07±18.42)pg/L和(218.93±27.55)pg/L］明显高于B级［(67.33±1.53)pg/L和(164.67±5.77)pg/L］，Plt;0.05；并且重度食管静脉曲张患者的血清内皮素和胰高血糖素浓度［(101.28±22.88)pg/L和(209.89±32.5)pg/L］明显高于未再出血组的重度食管静脉曲张患者［(59.95 ±7.19)pg/L和(179.71±10.43)pg/L］，Plt;0.05。结论nbsp; 血清内皮素、胰高血糖素显著升高可作为预测肝硬化食管静脉曲张破裂近期再出血的监测指标之一。 nbsp;nbsp;nbsp; ［关键词］nbsp; 肝硬化；食管静脉曲张破裂再出血； 内皮素；胰高血糖素 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; Studies on the relationship between endothelin1,glucagonnbsp; and esophageal and gastric varices rebleedingnbsp; in cirrhosis nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; ［Abstract］nbsp; Objectivenbsp; To explore the relationship betweennbsp; endothelin1,glucagon and esophageal and gastric varices rebleeding in cirrhosis.Methodsnbsp; The seral levels of endothelin1,glucagons from 31 inpatients of cirrhosis with esophageal and gastric varices bleeding,among them,18 patients with rebleeding in one week(rebleeding group),13 without rebleeding(non rebleeding group ) were detected by radio immunoassay (RIA) in different conditions.Resultsnbsp; The serum levels of endothelin1 and glucagon in rebleeding group［(101.28±22.88)pg/L and (209.89±32.50)pg/L］ were significantlynbsp; higher than that in non rebleeding group ［(60.38±5.78)pg/L and (172.92±16.39)pg/L］，Plt;0.05. In rebleeding group,the concentrations of endothilin1 and glucagon innbsp; the patients with childPugh C［(108.07±18.42)pg/L and(218.93±27.55)pg/L］ were markedly higher than that in thenbsp; patients with childpugh B ［(67.33±1.53)pg/L and(164.67±