再生障碍性贫血患者骨髓肾素血管紧张素系统表达的研究.docVIP

再生障碍性贫血患者骨髓肾素血管紧张素系统表达的研究 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：彭敏源，赵谢兰，高欣，雷瑚仪 【摘要】nbsp; 肾素血管紧张素系统（RAS）已被证明参与了骨髓造血细胞的生长增殖和分化，而再生障碍性贫血（AA）被认为是与骨髓造血细胞受损和造血微环境缺陷有关的疾病。为了探讨AA的发病机制，运用放射免疫方法检测22例AA患者骨髓和外周血肾素活性及AngⅠ、AngⅡ浓度，并以16例外周血常规和骨髓检查正常的患者为对照组，比较两组之间的差异。结果发现： AA组骨髓AngⅡ浓度低于对照组（Plt;0.01），AA组的骨髓AngⅡ浓度与外周血比较差异无统计学意义（P＞0.05），对照组的骨髓AngⅡ浓度较同组的外周血高（Plt;0.01），两组的肾素活性及AngⅠ浓度差异无统计学意义（Pgt;0.05）。结论： AA患者骨髓AngⅡ浓度降低，AA发病可能与其有关。 【关键词】nbsp; 再生障碍性贫血 　　Renin Angiotensin System in Bone Marrow ofnbsp; Patients with Aplastic Anemia 　　　Abstractnbsp;nbsp;nbsp; Renin-angiotensin system (RAS) has been shown to be involved in the growth，production，proliferation and differentiation of the bone marrow (BM) hematopoietic cells，while aplastic anemia (AA) is a disease in which proliferation ability of the BM hematopoietic cells is damaged with defective hematopoietic microenvironment. To investigated the pathogenesis of AA，the rennin activity，angiotensinⅠ(AngⅠ) and angiotensin Ⅱ(AngⅡ) concentration in peripheralnbsp; blood and BM ofnbsp; 22 AA patients were detected by radioimmunnoassay，16nbsp; nonhematological disease patients with nomal blood counts and BMnbsp; picture were used as control，and the differeence between two groups was compared.nbsp; The results showed thatnbsp; BM AngⅡconcentration in the AA patients was significantly lower than that in the control （Plt;0.01）. In nonhematological disease patients，AngⅡconcentrationnbsp; in BMnbsp; was significantly higher than that in peripheral blood，thenbsp; renin activities and AngⅠconcentrations werenbsp; notnbsp; significantly different in the two groups（Pgt;0.05）.nbsp; In conclusion，the decreased BM AngⅡconcentration in AAnbsp;nbsp; patients may be involved tonbsp; the pathogenesis of AA. 　　Key wordsnbsp;nbsp;nbsp; aplastic anemia; rennin angiotensin system; AngⅠ；nbsp; AngⅡ;nbsp; bone marrow hematopoietic cell nbsp;nbsp;nbsp; 肾素血管紧张素系统(renin-angiotensin system，RAS)被认为是调节血压电解质的内分泌系统，然而近年发现，该系