焦虑镇静催眠药课件.pptVIP

  Anxiolytic, Sedative-Hypnotic Drugs ?    School of pharmacology Wang zejian Anxiety Feeling of helplessness Difficulty in concentrating Irritability insomnia GI disturbances Muscle tension Excessive perspiration Palpitations Dry mouth Impending doom Dread(terror) Clinical Disorders Panic disorder Obsessive-compulsive disorder Post-traumatic stress disorder Social phobia Social anxiety disorder Generalized anxiety disorder Specific phobia Sedation Character: Decreased anxiety Decreased motor activity Decreased mental acuity Hypnosis Character: Increased tendency to sleep Induce the soporific state( Sleep)  Benzodiazepines  Pharmacological effects Mechanism of action Therapeutic uses Pharmacokinetics Adverse effects Precautions Pharmacological effects  1) Reduction of anxiety -At low doses, the drugs cause little sedation -Inhibiting neuronal circuits in the limbic system of the brain selectively Pharmacological effects 2) Sedative Pharmacological effect 3) Hypnotic action -at high doses, produce drowsiness sleep - higher CNS depression by increased dose Pharmacological effects 4) Anticonvulsant -Can exert anticonvulsant effects without marked central nervous system depression, so that mental and physiologic activity are relatively unaffected. Mechanism of Action GABAA receptor composition varies in different regions BNZs bind to receptors with alpha gamma subunits. BNZ binding “enhances” the effect of GABA on the Cl-channel BNZs exert no effect in the absence of GABA Mechanism of action Bind to benzodiazepine receptor of the GABAa receptor-chloride channel complex Leads to increased frequency of Cl- channel opening and Cl- conductance Facilitate GABA-mediated inhibition of neuronal activity, particularly in limbic and cortical areas of CNS